The vasculature: a therapeutic target in heart failure?
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چکیده
منابع مشابه
Protein kinase C in heart failure: a therapeutic target?
Heart failure (HF) afflicts about 5 million people and causes 300,000 deaths a year in the United States alone. An integral part of the pathogenesis of HF is cardiac remodelling, and the signalling events that regulate it are a subject of intense research. Cardiac remodelling is the sum of responses of the heart to causes of HF, such as ischaemia, myocardial infarction, volume and pressure over...
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HEART FAILURE, THE ULTIMATUM of various forms of myocardial disease, is associated with high mortality rate in this modern world (2). Multiple factors play important roles in the genesis of heart failure. The presence of left ventricular hypertrophy is a powerful predictor of the development of heart failure (3). It is believed that gradual deterioration of the hypertrophied left ventricle (LV)...
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Endothelium as a Therapeutic Target in Heart Failure Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1998 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.98.24.2652 1998;98:2652-2655 Circulation. http://circ.ahajournals.org/content/98/24/2652 World Wide Web at...
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Heart failure is a pressing public health problem with no curative treatment currently available. The existing therapies provide symptomatic relief, but are unable to reverse molecular changes that occur in cardiomyocytes. The mechanisms of heart failure are complex and multiple, but mitochondrial dysfunction appears to be a critical factor in the development of this disease. Thus, it is import...
متن کامل[Mitochondrial dynamics: a potential new therapeutic target for heart failure].
Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. These events allow the transmission of signaling messengers and exchange of metabolites within the cell. They have also been implicated in a variety of biological processes ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2021
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvab047